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A pdf Neuropeptide Gene Mutation and Ablation of PDF Neurons Each Cause Severe Abnormalities of Behavioral Circadian Rhythms in Drosophila
Disrupting a key brain chemical gene or its neurons causes serious daily behavior problems in fruit flies
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Abstract
Animals with mutant or ablated pdf neuropeptide genes display similar behavioral phenotypes.
- Both mutant and ablated animals entrained to light but became largely arrhythmic in constant conditions.
- A minority of each pdf variant showed weak to moderate free-running rhythmicity.
- Results support the role of LNv neurons as primary circadian pacemakers in Drosophila.
- PDF is implicated as the main circadian transmitter in this system.
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