Functional PDF Signaling in the Drosophila Circadian Neural Circuit Is Gated by Ral A-Dependent Modulation

May 11, 2016Neuron

Daily PDF Signals in the Fruit Fly's Body Clock Circuit Are Controlled by Ral A Protein

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Abstract

Responsiveness to the neuropeptide PDF in small LNvs varies daily, reaching a 10-fold increase around dawn.

  • Daily variations in PDF responsiveness in small LNvs are observed, persisting even in constant darkness.
  • This rhythmic responsiveness is independent of the PDF ligand and does not require rhythmic transcription of receptor genes.
  • The cycling of dopamine responsiveness aligns with that of PDF in small LNvs but does not occur in large LNvs.
  • RalA GTPase activity in small LNvs influences PDF responsiveness and circadian behavioral rhythms.
  • Cell-autonomous PDF signaling can counteract the circadian effects caused by reduced RalA activity.

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