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Changes in brain’s communication pathways after LSD treatment in people with major depression
Updated
Abstract
Essence
Higher-dose LSD was associated with white-matter microstructural changes that tracked antidepressant improvement in major depression.
Evidence
A diffusion tensor imaging substudy of 35 randomized patients with major depressive disorder, including 17 in the high-dose LSD group, found increased fractional anisotropy in several white-matter tracts and correlations with IDS symptom improvement at 2, 6, and 12 weeks.
Caveat
The imaging sample was small, and FA-symptom correlations do not prove that white-matter change caused antidepressant benefit.
Simplified
Psychedelic Science