Neurotoxicity of Micro- and Nanoplastics: A Comprehensive Review of Central Nervous System Impacts

Jan 21, 2026Environment & health (Washington, D.C.)

Brain Harm Caused by Tiny Plastic Particles: A Complete Review of Effects on the Nervous System

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Abstract

Micro- and (MNPs) are linked to various neurotoxic effects that may contribute to cognitive decline and motor impairments.

  • MNPs can cause neuronal damage and disrupt synaptic functions.
  • Exposure to MNPs is associated with and blood-brain barrier disruption.
  • Potential mechanisms of MNPs toxicity include oxidative stress and immune responses.
  • MNPs may interact with other pollutants, complicating their health effects.
  • There is a significant need for improved pollution control and detection technologies related to MNPs.

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Key numbers

26,076 μg/g
in Brain Tissue Concentration
Median concentration of in brain tissues from dementia patients.
174,959 plastic particles
Annual Plastic Particle Ingestion
Estimated annual ingestion of plastic particles per person.
26–130 particles
Daily Inhaled
Estimated number of inhaled into the lungs daily.

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