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Nicotinamide: Oversight of Metabolic Dysfunction Through SIRT1, mTOR, and Clock Genes
Nicotinamide's role in controlling metabolism through SIRT1, mTOR, and body clock genes
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Abstract
Nicotinamide may improve glucose utilization and limit mitochondrial dysfunction in metabolic disorders.
- Metabolic disorders, including diabetes, affect all body systems and current treatments do not prevent disease progression.
- Nicotinamide interacts with key pathways like SIRT1, mTOR, AMPK, and clock genes that are involved in metabolic regulation.
- The compound could help reduce oxidative stress and support cellular survival through mechanisms such as autophagy.
- Complex interactions among nicotinamide, SIRT1, mTOR, and other factors may influence metabolic homeostasis.
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