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The mechanistic target of rapamycin (mTOR) and the silent mating-type information regulation 2 homolog 1 (SIRT1): oversight for neurodegenerative disorders
The roles of mTOR and SIRT1 in controlling brain disorders that cause nerve cell loss
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Abstract
The pathways of the mechanistic target of rapamycin (mTOR) and SIRT1 are closely integrated and may impact multiple neurodegenerative disorders.
- Neurodegenerative disorders are increasing in incidence due to the aging global population.
- mTOR affects apoptosis and autophagy and is linked to Alzheimer's disease, Huntington's disease, and Parkinson's disease.
- SIRT1 may regulate stem cell growth and protect neurons from programmed cell death.
- Precision in controlling mTOR and SIRT1 is crucial to prevent the progression of neurodegenerative disorders.
- Further research into these pathways could lead to effective and safe treatments for neurodegenerative disorders.
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