The roles of mTOR and SIRT1 in controlling brain disorders that cause nerve cell loss

The pathways of the mechanistic target of rapamycin (mTOR) and SIRT1 are closely integrated and may impact multiple neurodegenerative disorders.

• Neurodegenerative disorders are increasing in incidence due to the aging global population.
• mTOR affects apoptosis and autophagy and is linked to Alzheimer's disease, Huntington's disease, and Parkinson's disease.
• SIRT1 may regulate stem cell growth and protect neurons from programmed cell death.
• Precision in controlling mTOR and SIRT1 is crucial to prevent the progression of neurodegenerative disorders.
• Further research into these pathways could lead to effective and safe treatments for neurodegenerative disorders.

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