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Night shift work may be linked to breast cancer risk and its causes.
Updated
Abstract
Essence
This review argues that night shift work may raise breast cancer risk through and related biological pathways, while informing more precise risk stratification.
Evidence
This narrative review synthesizes mechanistic hypotheses, putative biomarkers, and case-control and cohort evidence on breast cancer risk in female night shift workers.
Caveat
Because it is a review of heterogeneous observational and mechanistic evidence, exposure misclassification and confounding limit any firm causal conclusion.
Simplified
Key numbers
8.58
Increased Risk of Breast Cancer
Odds ratio for breast cancer risk associated with ≥10 years of night shift work in Mexican women.
53%
Significant Association
Percentage of studies reporting a positive association between night shift work and breast cancer risk since 1996.
↑ 8-OH-dG
Elevated Oxidative Stress
Marker of oxidative DNA damage found higher in night shift workers compared to day shift workers.
Circadian Biology