Neuroscience bulletinJun 15, 2021

Non-movement Symptoms of Parkinson's Disease, Especially Problems with Body Clock Rhythms

Circadian Biology Weekly Brief ↗PubMed ↗DOI ↗

Updated Apr 4, 2026

Abstract

Circadian rhythm dysregulation is associated with Parkinson's disease (PD) and may manifest before motor symptoms appear.

Parkinson's disease is characterized by both motor and non-motor symptoms.
Circadian rhythm dysregulation is one of the most challenging non-motor features of PD.
Altered circadian rhythms have been linked to the pathogenesis of PD.
Research indicates that circadian rhythm-related genes may play a role in PD.
Understanding circadian disorders in PD could improve management strategies.

Simplified

Parkinson's disease (PD) is the second most common neurodegenerative disease, which manifests with both motor and non-motor symptoms. Circadian rhythm dysregulation, as one of the most challenging non-motor features of PD, usually appears long before obvious motor symptoms. Moreover, the dysregulated circadian rhythm has recently been reported to play pivotal roles in PD pathogenesis, and it has emerged as a hot topic in PD research. In this review, we briefly introduce the circadian rhythm and circadian rhythm-related genes, and then summarize recent research progress on the altered circadian rhythm in PD, ranging from clinical features to the possible causes of PD-related circadian disorders. We believe that future comprehensive studies on the topic may not only help us to explore the mechanisms of PD, but also shed light on the better management of PD.

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Competing interests

The authors declare that they have no conflict of interest.

PubMed

Non-movement Symptoms of Parkinson's Disease, Especially Problems with Body Clock Rhythms

Abstract

Full Text

Funding

Competing interests

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Abstract

Full Text

Funding

Competing interests

Related papers

You found one interesting study. We’ll send the next 7.

What Lands in Your Inbox Each Week:

Recent issues from the circadian biology brief