Recent Progress in Non-motor Features of Parkinson’s Disease with a Focus on Circadian Rhythm Dysregulation

Jun 15, 2021Neuroscience bulletin

Non-movement Symptoms of Parkinson's Disease, Especially Problems with Body Clock Rhythms

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Abstract

Circadian rhythm dysregulation is associated with Parkinson's disease (PD) and may manifest before motor symptoms appear.

Parkinson's disease is characterized by both motor and non-motor symptoms.
Circadian rhythm dysregulation is one of the most challenging non-motor features of PD.
Altered circadian rhythms have been linked to the pathogenesis of PD.
Research indicates that circadian rhythm-related genes may play a role in PD.
Understanding circadian disorders in PD could improve management strategies.

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Parkinson's disease (PD) is the second most common neurodegenerative disease, which manifests with both motor and non-motor symptoms. Circadian rhythm dysregulation, as one of the most challenging non-motor features of PD, usually appears long before obvious motor symptoms. Moreover, the dysregulated circadian rhythm has recently been reported to play pivotal roles in PD pathogenesis, and it has emerged as a hot topic in PD research. In this review, we briefly introduce the circadian rhythm and circadian rhythm-related genes, and then summarize recent research progress on the altered circadian rhythm in PD, ranging from clinical features to the possible causes of PD-related circadian disorders. We believe that future comprehensive studies on the topic may not only help us to explore the mechanisms of PD, but also shed light on the better management of PD.

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Recent Progress in Non-motor Features of Parkinson’s Disease with a Focus on Circadian Rhythm Dysregulation

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