Noradrenaline and serotonin reuptake inhibition as clinical principles:a review of antidepressant efficacy

Reboxetine may improve social functioning significantly more than fluoxetine in the treatment of major depression.

• Numerous studies have compared the efficacy of selective serotonin reuptake inhibitors (SSRIs) and noradrenaline reuptake inhibitors (NRIs) with varied selectivity.
• Most studies indicate no significant differences in response rates or subtype responsivity between SSRIs and NRIs.
• Some studies suggest NRIs could be superior to SSRIs in addressing retardation symptoms.
• SSRIs may be more effective than NRIs for anxiety symptoms.
• NRIs might be more effective than SSRIs in cases of severe depression.
• Reboxetine has been shown to be at least as effective as imipramine, desipramine, and fluoxetine.

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