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Abstract
Combination treatment with BI 1820237 and survodutide resulted in a 22% bodyweight reduction in diet-induced obese mice.
- BI 1820237 reduced food intake and slowed gastric emptying in lean mice in a dose-dependent manner.
- When combined with survodutide, BI 1820237 enhanced weight loss effects significantly more than survodutide alone.
- The combination therapy showed a 265% increase in efficacy at a dose of 11.7 nmol/kg.
- Diet-induced obese mice did not experience significant weight loss with BI 1820237 alone.
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