American heart journal

Changes in Heart Stress and Injury Markers During Glucagon-Like Peptide-1 Treatment in Type 2 Diabetes

Updated

Abstract

In a study of 14,752 adults with type 2 diabetes, 529 major adverse cardiovascular events (MACE) were recorded over a median follow-up of 1,480 days.

  • Baseline levels of NT-proBNP were strongly associated with increased risks of MACE, all-cause mortality, cardiovascular death, and hospitalization for heart failure.
  • A 1-year increase in NT-proBNP predicted higher risk for MACE and cardiovascular death.
  • Baseline cTnI also indicated increased risk of adverse outcomes, but the relationship was nonlinear, with significant risk primarily above the median level.
  • Neither baseline NT-proBNP nor baseline cTnI modified the treatment effects of exenatide on MACE.
  • Exenatide was associated with lower rates of cardiovascular deaths and hospitalizations for heart failure at higher baseline cTnI concentrations.

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Funding

Competing interests

Conflict of interest PW reports grant income from Roche Diagnostics, AstraZeneca, Boehringer Ingelheim, and Novartis, and speaker fees from Novo Nordisk and Raisio Nutrition. JBB reports salary support from clinical trial contracts to his employer by Corcept, Dexcom, GentiBio, and Novo Nordisk; personal compensation for consulting from Aardvark Therapeutics, Altimmune, Alveus Therapeutics, Amgen, Antag, Aqua Medical, AstraZeneca, Boehringer-Ingelheim, Corcept Therapeutics, Dexcom, Eli Lilly, embecta, General Medicines Inc, GentiBio, Insulet, Kayothera, Metsera, MiniMed, Novo Nordisk, Recordati, Sparrow Pharmaceuticals, Tandem, Vertex, vTv Therapeutics, and Zealand; stock/options in Glyscend, Mellitus Health, Metsera, Pendulum Therapeutics, Praetego, and Stability Health. HS is on the advisory board and speaker’s bureau of Boehringer Ingelheim, Novo Nordisk, Sanofi-Aventis, Amgen, AstraZeneca, Bayer, Eli Lilly, Kapsch, MSD, and Daiichi Sankyo. AFH reports research support and/or honoraria from AstraZeneca, Boehringer Ingleheim, Boston Scientific Corporation, Bristol Myers Squibb, Eidos Therapeutics, Intellia, Intercept, Merck, Novartis, Novo Nordisk, Prolaio, TikkunLev Therapeutics, Inc. RRH reports personal fees from Lilly, Merck KGaA, MitoRx, Novartis and Owen Mumford Ltd. SHS reports researching funding from AstraZeneca. RJM reports research support and/or honoraria from Abbott, Alleviant Medical, American Regent, Amgen, AstraZeneca, Bayer, Boehringer Ingelheim, CVRx, Cytokinetics, Daiichi Sankyo, Edwards, Eli Lilly, Endotronix, Lexicon, Medtronic, Merck, Novartis, Novo Nordisk, Otsuka, Pfizer, Pharmacosmos, Reprieve Cardiovascular, Respicardia, Roche, Rocket Pharmaceuticals, Vifor, Windtree Therapeutics, and Zoll. All other authors report no relevant disclosures.
PubMed

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