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The nuclear receptor REV‐ERBα is required for the daily balance of carbohydrate and lipid metabolism
The REV-ERBα protein is needed for daily balance between sugar and fat metabolism
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Abstract
Chow-fed Rev-erbα(-/-) mice displayed 2.5-fold increased adiposity and approximately 10% mild hyperglycemia.
- Mutations in clock genes, such as REV-ERBα, may influence diabetes and obesity.
- Chow-fed Rev-erbα(-/-) mice utilize more fatty acids during the daytime compared to their wild-type counterparts.
- A 24-hour fasting period in Rev-erbα(-/-) mice favors fatty acid mobilization while reducing glycogen use and gluconeogenesis.
- High-fat feeding exacerbates metabolic disturbances in Rev-erbα(-/-) mice, including increased expression of lipogenic factors.
- The lipoprotein lipase (Lpl) gene, crucial for lipid metabolism, is significantly up-regulated in muscle and adipose tissue of Rev-erbα(-/-) mice.
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