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Rev-erbα, a Heme Sensor That Coordinates Metabolic and Circadian Pathways
Rev-erbalpha, a heme sensor linking metabolism and the body’s daily clock
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Abstract
Heme binds reversibly to the nuclear receptor Rev-erbalpha, influencing metabolic processes.
- Heme is an iron-containing molecule essential for various metabolic functions and circadian regulation.
- Rev-erbalpha acts as a negative regulator within the circadian clock.
- The binding of heme to Rev-erbalpha affects its interaction with a corepressor complex.
- Heme is associated with the suppression of gene expression related to glucose production in the liver.
- Rev-erbalpha may function as a sensor for heme, linking circadian rhythms with glucose and energy metabolism.
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