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Stress-related functions and interactions of specific brainstem neurons that respond to hormones controlling metabolism and hormone release
Updated
Abstract
The caudal nucleus of the solitary tract () integrates signals from various stressors, highlighting the role of glucagon-like peptide-1 () and prolactin-releasing peptide () neurons.
- GLP-1 and PrRP neurons in the cNTS are involved in coordinating responses to both interoceptive and psychogenic stress.
- Co-activation of GLP-1 and PrRP neurons occurs in reaction to stressful stimuli, indicating their collaborative function.
- PrRP neurons are positioned downstream of GLP-1 neurons, suggesting a hierarchical relationship in stress response mechanisms.
- The review identifies potential targets for future research focused on stress-related disorders involving these neuronal pathways.
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