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The role of nucleus of the solitary tract glucagon‐like peptide‐1 and prolactin‐releasing peptide neurons in stress: anatomy, physiology and cellular interactions
Stress-related functions and interactions of specific brainstem neurons that respond to hormones controlling metabolism and hormone release
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Abstract
The caudal nucleus of the solitary tract () integrates signals from various stressors, highlighting the role of glucagon-like peptide-1 () and prolactin-releasing peptide () neurons.
- GLP-1 and PrRP neurons in the cNTS are involved in coordinating responses to both interoceptive and psychogenic stress.
- Co-activation of GLP-1 and PrRP neurons occurs in reaction to stressful stimuli, indicating their collaborative function.
- PrRP neurons are positioned downstream of GLP-1 neurons, suggesting a hierarchical relationship in stress response mechanisms.
- The review identifies potential targets for future research focused on stress-related disorders involving these neuronal pathways.
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