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Abstract
Skeletal muscle clock gene expression is altered by obesity and weight loss, with mRNA levels significantly changing in response to Roux-en-Y gastric bypass surgery.
- Obesity is associated with increased and decreased levels of specific clock gene mRNA in women compared to normal-weight controls.
- After Roux-en-Y gastric bypass surgery, clock gene mRNA levels in obese women were restored to those of normal-weight controls.
- In obese men, clock gene mRNA levels were decreased compared to normal-weight men.
- The expression of most other clock genes remained unchanged by obesity or weight loss in both women and men.
- Clock gene expression was inversely correlated with plasma lipids, suggesting a link between lipid levels and circadian regulation.
- Palmitate treatment altered clock gene expression profiles in myotubes, indicating that dyslipidemia may disrupt circadian functions.
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