Designing functional protein binders in a single step using BindCraft

Experimental success rates for the automated protein binder design pipeline BindCraft range from 10-100%.

• BindCraft generates protein binders with nanomolar affinity without the need for high-throughput screening.
• The system can design binders even when known binding sites are not available.
• Successful designs have targeted a variety of proteins, including cell-surface receptors and allergens.
• Designed binders have shown the ability to reduce IgE binding to allergens in patient samples.
• The pipeline has been applied to modulate gene editing activity and decrease cytotoxicity from foodborne toxins.
• Certain binders can redirect virus capsids for more precise gene delivery.

Simplified