Oxytocin Receptor Is Differentially Expressed in Mouse Endometrium and Embryo during Blastocyst Implantation

Feb 20, 2007Annals of the New York Academy of Sciences

Oxytocin receptor levels differ between mouse womb lining and embryo during early embryo attachment

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Abstract

The oxytocin receptor (OTR) mRNA expression was detected in mouse oocytes and embryos up to the blastocyst stage.

  • OTR expression was observed in the uterine tissue of 5- to 8-week-old female mice during days 4 to 10 of pregnancy.
  • A significant increase in OTR mRNA was found immediately after fertilization, followed by a gradual decrease after the four-cell stage.
  • The differential expression of OTR suggests a role in embryonic apposition and invasion during implantation.
  • The interaction between OTR and hormones used in ovulation induction for in vitro fertilization (IVF) may influence endometrial receptivity.

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