Up-regulation of oxytocin receptors in non-pregnant rat myometrium by isoproterenol: effects of steroids

May 20, 1999The Journal of endocrinology

Increase of oxytocin receptors in the uterine muscle of non-pregnant rats caused by isoproterenol and influenced by steroid hormones

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Abstract

Estrogen treatment increased both OTR mRNA production and maximal binding of [3H]-oxytocin in rat myometrium.

  • Beta2-adrenoceptor activation may regulate oxytocin receptor (OTR) expression in the uterus.
  • Isoproterenol combined with estrogen treatment enhanced contractile response to oxytocin without increasing OTR mRNA or binding.
  • Progesterone alone did not alter OTR mRNA or binding, but it induced OTR expression when combined with isoproterenol.
  • Progesterone suppressed the effects of estrogen on OTR mRNA and binding when administered together.
  • The addition of isoproterenol abolished progesterone's suppressive effect on estrogen's influence and enhanced the contractile response.

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