Full text is available at the source.
Paeonol alleviates primary dysmenorrhea in mice via activating CB2R in the uterus
Paeonol reduces menstrual pain in mice by activating a specific receptor in the uterus
AI simplified
Abstract
Oral administration of paeonol reduced dysmenorrhea pain and inflammatory mediator expression in mouse uterine tissues.
- Paeonol decreased the levels of PGE2 and TNF-α in the uterus, which are associated with pain and inflammation.
- It was distributed in lesions of the uterus, indicating localized action.
- Paeonol nearly completely inhibited uterine contractions induced by oxytocin, high potassium, and calcium.
- The inhibitory effects of paeonol on uterine contractions were reversed by antagonists of the CB2 receptor and the MAPK pathway.
- Paeonol blocked calcium channels and reduced calcium influx in uterine smooth muscle cells via CB2 receptors.
- Molecular docking results indicated that paeonol fits well with the binding site of the CB2 receptor.
AI simplified