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Pancreatic β cell enhancers regulate rhythmic transcription of genes controlling insulin secretion
Cell enhancers in the pancreas control daily rhythms of genes that manage insulin release
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Abstract
β cell clock ablation in adult mice caused severe glucose intolerance.
- Insulin secretion showed pronounced oscillation, synchronized with the expression of genes involved in insulin release.
- CLOCK and BMAL1 proteins were found to colocalize with the pancreatic transcription factor PDX1 in active enhancers.
- Distinct enhancers were identified for circadian control of metabolism, separate from those regulating rhythmic gene expression in the liver.
- Disruption of circadian cycles is associated with metabolic disorders, including type 2 diabetes.
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