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PAS Domain-Mediated WC-1/WC-2 Interaction Is Essential for Maintaining the Steady-State Level of WC-1 and the Function of Both Proteins in Circadian Clock and Light Responses of Neurospora
Interaction between WC-1 and WC-2 proteins is essential for maintaining WC-1 levels and their role in Neurospora's internal clock and light response
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Abstract
The steady-state level of WC-1 protein is extremely low in wc-2 knockout strains.
- WC-1 protein levels are regulated by both FRQ and WC-2 through different mechanisms after transcription.
- The low expression of WC-1 in wc-2 knockout strains is independent of wc-1 transcription and FRQ protein levels.
- The PAS domain of WC-2 is involved in the interaction with both WC-1 and FRQ in living organisms.
- Interactions between WC-1 and WC-2 are crucial for maintaining the necessary levels of WC-1 and proper function in circadian and light responses.
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