How PER and WDR5 protein interactions affect the mammal's internal biological clock

WDR5 directly binds to the CRY binding domain regions of PER1 and PER2, influencing circadian rhythm regulation.

• WDR5 is involved in the competition between multiple protein complexes that include PER1 and PER2.
• PER2 interacts with WDR5 through a specific motif, affecting its binding dynamics with CRY and other proteins.
• PER1 predominantly binds WDR5 via a different motif, facilitating the formation of distinct protein complexes.
• Inhibitors targeting WDR5's WIN site disrupt PER1 interactions, which may influence the expression of key circadian genes.
• WDR5 plays a significant role in modulating the circadian feedback loops associated with BMAL1 and CLOCK.

Simplified