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Expressions of per1 Clock Gene and Genes of Signaling Peptides Vasopressin, Vasoactive Intestinal Peptide, and Oxytocin in the Suprachiasmatic and Paraventricular Nuclei of Hypertensive TGR[mREN2]27 Rats
Daily patterns of clock and signaling genes in brain areas controlling body rhythms in high blood pressure rats
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Abstract
TGR hypertensive rats exhibited an inverted circadian blood pressure profile.
- The expression of the clock gene per1 displayed a distinct circadian rhythm in both the hypothalamic suprachiasmatic nucleus (SCN) and paraventricular nucleus (PVN) without differences between TGR and control rats.
- Vasopressin (AVP) expression was rhythmic in the SCN for both TGR and control rats, with higher levels observed in TGR rats.
- No significant differences in AVP expression were found in the PVN between both strains.
- Vasoactive intestinal peptide (VIP) in the SCN and oxytocin (OXT) in the PVN showed no differences between TGR and control rats.
- Findings suggest that downstream changes from the SCN may contribute to the altered blood pressure rhythm in TGR hypertensive rats.
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