Cellular and molecular neurobiology

Daily patterns of clock and signaling genes in brain areas controlling body rhythms in high blood pressure rats

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Abstract

TGR hypertensive rats exhibited an inverted circadian blood pressure profile.

  • The expression of the clock gene per1 displayed a distinct circadian rhythm in both the hypothalamic suprachiasmatic nucleus (SCN) and paraventricular nucleus (PVN) without differences between TGR and control rats.
  • Vasopressin (AVP) expression was rhythmic in the SCN for both TGR and control rats, with higher levels observed in TGR rats.
  • No significant differences in AVP expression were found in the PVN between both strains.
  • Vasoactive intestinal peptide (VIP) in the SCN and oxytocin (OXT) in the PVN showed no differences between TGR and control rats.
  • Findings suggest that downstream changes from the SCN may contribute to the altered blood pressure rhythm in TGR hypertensive rats.

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