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Period circadian regulator 2-mediated steroid hormone synthesis by regulating transcription of steroidogenic acute regulatory protein in porcine granulosa cells
How the circadian protein Period 2 controls steroid hormone production by regulating a key transport protein in pig ovarian cells
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Abstract
Knockdown of Per2 significantly elevated progesterone levels in ovarian granulosa cells.
- Per2 was identified in ovarian granulosa cells and exhibited a circadian expression pattern.
- Interference with Per2 expression increased levels of StAR, a protein involved in steroid hormone production.
- The rhythm of other clock-related genes was not altered by Per2 knockdown.
- Per2 was shown to form complexes with PPARγ, influencing the activity of the PPARγ:RXRα heterodimer.
- The PPARγ:RXRα complex is capable of directly binding to the StAR promoter to regulate its transcription.
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