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Circadian Clock genes Per2 and clock regulate steroid production, cell proliferation, and luteinizing hormone receptor transcription in ovarian granulosa cells
Circadian Clock Genes Per2 and Clock Influence Hormone Production, Cell Growth, and Hormone Receptor Levels in Ovarian Follicle Cells
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Abstract
Treatment with Per2 and Clock siRNAs resulted in a decrease in granulosa cells and LHr expression.
- Circadian Clock genes may influence the estrous cycle in female animals.
- Per2 siRNA treatment did not stimulate estradiol production or P450arom expression.
- Clock siRNA treatment inhibited estradiol production and P450arom mRNA expression.
- Per2 siRNA increased progesterone production in FSH-treated granulosa cells, while Clock siRNA had no effect.
- StAR mRNA expression increased with Per2 siRNA treatment but remained unchanged with Clock siRNA.
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