Perioperative Use of GLP-1 Receptor Agonists in Patients Undergoing Cardiac Procedures: A Scoping Review

📖 Top 30% JournalJan 17, 2025Heart, lung & circulation

Use of GLP-1 Drugs Around Heart Surgery: A Broad Review

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Abstract

Three studies were identified focusing on daily dosed GLP-1 receptor agonists in patients undergoing cardiac surgery.

No studies were found on the use of GLP-1 receptor agonists during cardiac catheterisation or trans-oesophageal echocardiograms.
There is a lack of research on the risk of pulmonary aspiration in patients using GLP-1 receptor agonists during cardiac procedures.
GLP-1 receptor agonists may provide benefits for weight loss, glycaemic control, and cardiovascular health in the perioperative setting.
Current guidelines for perioperative management of GLP-1 receptor agonists are highly contradictory.
Existing literature suggests a theoretical risk of pulmonary aspiration for patients using GLP-1 receptor agonists, warranting a cautious approach.

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BACKGROUND: Glucagon-like peptide-1 receptor agonist (GLP-1RA) therapies are increasingly used for the treatment of type 2 diabetes mellitus and obesity. Despite growing awareness of potentially increased risk of pulmonary aspiration due to delayed gastric emptying, the risks and benefits of their perioperative use in patients undergoing cardiac procedures remains unexplored. A scoping review was performed to investigate the perioperative GLP-1RA use in patients undergoing cardiac procedures and recommendations.

METHOD: PubMed and Ovid MEDLINE were searched up to April 2024 to identify English-language studies on the perioperative use of weekly and daily dosed GLP-1RAs in adult patients undergoing cardiac procedures (including cardiac surgery, trans-oesophageal echocardiograms, and cardiac catheterisation procedures).

RESULTS: Three studies were identified, which investigated daily dosed GLP-1RAs in patients undergoing cardiac surgery. No studies were found investigating GLP-1RA use in cardiac catheterisation or trans-oesophageal echocardiograms procedures, and none which specifically examined risk of pulmonary aspiration in patients using GLP-1RAs undergoing cardiac procedures.

CONCLUSIONS: GLP-1RAs are beneficial for perioperative weight loss, glycaemic control, and cardiovascular health. Existing guidelines and consensus recommendations are highly contradictory on perioperative GLP-1RA management. Although no known published case reports exist to date of pulmonary aspiration in patients using GLP-1RAs undergoing cardiac procedures, non-cardiac surgical literature strongly suggests that patients are at theoretical risk and a cautious approach is advised in the absence of robust evidence informing recommendations for optimal withholding periods.

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