Perioperative management of patients on GLP-1 receptor agonists: Risks, recommendations, and future directions—A narrative review

🎖️ Top 10% JournalMay 16, 2025Journal of clinical anesthesia

Managing surgery for patients using GLP-1 medicines: risks, advice, and future ideas

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Abstract

Patients on glucagon-like peptide-1 receptor agonists (GLP-1RAs) may have an increased risk of gastric content retention during surgery.

  • GLP-1RAs are linked to delayed gastric emptying.
  • There is a potential risk for pulmonary aspiration in patients using GLP-1RAs during anesthesia.
  • Current evidence indicates that patients on GLP-1RAs may present with a full stomach when undergoing surgery.
  • Recommendations for managing these patients include careful medication assessment and additional monitoring.
  • Preventive measures such as pre-anesthesia gastric ultrasound and rapid sequence induction may be beneficial.
  • Further research is necessary to develop comprehensive guidelines for the perioperative management of patients taking GLP-1RAs.

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