BMC microbiologySep 28, 2024

Peritoneal dialysis is linked to increased microbial production of sesquiterpene and triterpene compounds in patients with end-stage kidney disease

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Updated Apr 2, 2026

Abstract

Shotgun metagenomic sequencing of fecal samples revealed increased complexity in gut microbiota interactions among patients undergoing for end-stage renal disease.

Gut microbiota interactions in patients receiving peritoneal dialysis are more complex compared to those not receiving dialysis.
Increased aggregation characteristics of gut microbiota interactions were observed in patients undergoing peritoneal dialysis.
The gut microbiota in peritoneal dialysis patients may drive the production of specific compounds, such as sesquiterpenes and triterpenes.
These compounds could be linked to enhanced blood purification and improved circulation in patients receiving dialysis.

Simplified

The concept of the is gaining significant attention due to the close relationship between gut microbiota and kidney disease. is recognized as a crucial renal replacement therapy for end-stage renal disease (ESRD). The alterations in gut microbiota and related mechanisms after receiving this dialysis method are not fully understood. This study conducted shotgun metagenomic sequencing on fecal samples from 11 end-stage renal disease patients who did not receive dialysis (ESRD_N) and 7 patients who received peritoneal dialysis (ESRD_P). After quality control and correlation analysis of the data, our study is aimed at exploring the impact of peritoneal dialysis on the gut microbiota and health of ESRD patients. Our research findings indicate that the complexity and aggregation characteristics of gut microbiota interactions increase in ESRD_P. In addition, the gut microbiota drives the biosynthesis pathways of sesquiterpenes and triterpenes in ESRD_P patients, which may contribute to blood purification and improve circulation. Therefore, our research will lay the foundation for the prevention and treatment of ESRD.

Key numbers

Participants

11 ESRD_N patients and 7 ESRD_P patients were included.

Differential Microbial Species

Relative abundance changes were analyzed between ESRD_N and ESRD_P groups.

Significantly Changed KEGG Pathways

These pathways were linked to microbial gene changes in ESRD_P patients.

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Funding

Competing interests

The authors declare no competing interests.

PubMed

Peritoneal dialysis is linked to increased microbial production of sesquiterpene and triterpene compounds in patients with end-stage kidney disease

Abstract

Key numbers

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Abstract

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Full Text

Funding

Competing interests

Related papers

You found one interesting study. We’ll send the next 7.

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Recent issues from the gut-brain axis brief