Drugs that may slow immune aging and chronic inflammation: senolytics, senomorphics, and new treatments

Ageing is associated with progressive immune dysfunction characterized by immunosenescence.

• Immunosenescence affects both innate and adaptive immunity.
• Ageing leads to reduced production of nave T and B cells.
• There is an accumulation of senescent immune cells with age.
• The ability to recognize pathogens is impaired in older individuals.
• A persistent low-grade inflammatory state, known as inflammaging, occurs even without infection.
• These changes contribute to increased susceptibility to infections and poor vaccine responses.

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