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Effect of photic stimuli disturbing overt circadian rhythms on the dorsomedial and ventrolateral SCN rhythmicity
How light that disrupts visible daily rhythms affects timing signals in two parts of the brain's biological clock
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Abstract
Constant light exposure seemingly abolished the c-Fos rhythm in the whole suprachiasmatic nucleus (SCN).
- The rhythm of c-Fos-immunoreactive cells persisted in the ventrolateral (vl) and dorsomedial (dm) parts of the SCN despite constant light.
- In the dm-SCN, the c-Fos rhythm was phase-delayed by about 4 hours under constant light.
- The PER1-immunoreactive rhythm was only slightly affected in the dm-SCN during constant light.
- In the vl-SCN, the c-Fos rhythm may be delayed by 5-6 hours compared to previously reported patterns.
- The rhythm of PER1 in the vl-SCN appeared out of phase with that observed in darkness.
- After a 9-hour light pulse, the PER1 rhythm in the vl-SCN was abolished, while the dm-SCN showed only slight changes.
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