Aberrant PLAC8 expression characterizes glioblastoma with temozolomide resistance and an immunosuppressive microenvironment

Elevated PLAC8 expression is associated with poorer survival rates in glioblastoma patients.

• PLAC8 acts as a novel mediator of resistance to the chemotherapeutic agent temozolomide in IDH-WT glioblastoma.
• Higher levels of PLAC8 are correlated with advanced tumor grades and poorer prognosis.
• Consistent upregulation of PLAC8 occurs in both temozolomide-resistant glioblastoma cells and patients treated with temozolomide.
• PLAC8 may regulate sensitivity to temozolomide through the AKT-mTOR signaling pathway.
• Increased PLAC8 expression correlates with immune cell infiltration and an immunosuppressive tumor environment, which may affect immunotherapy outcomes.

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