Characterization of the plasma metabolome and lipidome in response to sleeve gastrectomy and gastric bypass surgeries reveals molecular patterns of surgical weight loss

Significant changes in the plasma metabolome and lipidome were observed in 104 obese adults after bariatric surgery over 12 months.

• Rapid early changes included decreases in branched-chain amino acids, aromatic amino acids, alanine, and aspartate, along with increases in glycine, serine, arginine, and citrulline.
• Many triglyceride species showed significant decreases, while levels of phosphatidylcholines and phosphatidylethanolamines increased.
• Changes in metabolites related to energy metabolism were noted, but only became apparent after 12 months.
• Differences in primary and secondary bile acids were observed based on the type of bariatric surgery, particularly with glycohyocholate and glyco-beta-muricholate.

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