Full text is available at the source.
Abstract
PCB-containing lipid nanoparticles (LNPs) demonstrate higher mRNA transfection efficiency than PEG-containing LNPs.
- In vitro studies indicate that PCB-containing LNPs outperform PEG-containing LNPs in mRNA delivery across various cell types.
- In vivo studies in mice show that PCB-containing LNPs have greater therapeutic efficacy compared to PEG counterparts.
- Enhanced endosomal escape is identified as the mechanism behind the improved performance of PCB-containing LNPs.
- PCB formulations present a safe immunotoxicity profile, enabling their use in repeated administrations without loss of efficacy.
- These findings suggest PCB-containing LNPs could serve as a robust mRNA delivery system for potential clinical use.
Simplified