Polysaccharides Extracted from Old Stalks of Asparagus officinalis L. Improve Nonalcoholic Fatty Liver by Increasing the Gut Butyric Acid Content and Improving Gut Barrier Function

AP intervention reduces blood lipids and liver lipids in mice with NAFLD.

• AP intervention is associated with reduced liver injury and inflammation in NAFLD model mice.
• Changes in gut microbiota composition were observed following AP intervention, specifically an increase in butyric acid-producing bacteria.
• AP intervention resulted in higher plasma concentrations of butyric acid.
• Regulation of the AMPK/SREBPs signaling pathway was affected by AP intervention, impacting liver fat synthesis.
• Gut barrier function improved with AP intervention, leading to decreased plasma LPS levels.
• The LPS/TLR4/NF-κB signaling pathway was inhibited, which may contribute to reduced inflammation in NAFLD.

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