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Pomegranate Polyphenols and Extract Inhibit Nuclear Factor of Activated T-Cell Activity and Microglial Activation In Vitro and in a Transgenic Mouse Model of Alzheimer Disease
Pomegranate compounds reduce immune cell activity and brain inflammation in lab tests and an Alzheimer’s mouse model
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Abstract
Three months of pomegranate extract supplementation significantly decreased the path length to escape in 12-mo-old amyloid precursor protein/presenilin 1 (APP/PS1) transgenic mice (P < 0.05).
- Pomegranate feeding resulted in lower levels of tumor necrosis factor α (TNF-α) in the brains of treated mice compared to controls (P < 0.05).
- Nuclear factor of activated T-cell (NFAT) transcriptional activity was significantly reduced in the brains of pomegranate-fed mice compared to control-fed mice (P < 0.05).
- Immunocytochemistry revealed that pomegranate-fed mice exhibited reduced microgliosis and amyloid β plaque deposition compared to 12-mo-old control mice (P < 0.05).
- One month of pomegranate extract feeding increased spontaneous alternations in a T-maze test compared to control-fed mice (P < 0.05).
- Cell culture studies indicated that two polyphenol components of pomegranate extract, punicalagin and ellagic acid, decreased Aβ-stimulated TNF-α secretion by murine microglia (P < 0.05).
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