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Pomegranate compounds reduce immune cell activity and brain inflammation in lab tests and an Alzheimer’s mouse model
Updated
Abstract
Three months of pomegranate extract supplementation significantly decreased the path length to escape in 12-mo-old amyloid precursor protein/presenilin 1 (APP/PS1) transgenic mice (P < 0.05).
- Pomegranate feeding resulted in lower levels of tumor necrosis factor α (TNF-α) in the brains of treated mice compared to controls (P < 0.05).
- Nuclear factor of activated T-cell (NFAT) transcriptional activity was significantly reduced in the brains of pomegranate-fed mice compared to control-fed mice (P < 0.05).
- Immunocytochemistry revealed that pomegranate-fed mice exhibited reduced microgliosis and amyloid β plaque deposition compared to 12-mo-old control mice (P < 0.05).
- One month of pomegranate extract feeding increased spontaneous alternations in a T-maze test compared to control-fed mice (P < 0.05).
- Cell culture studies indicated that two polyphenol components of pomegranate extract, punicalagin and ellagic acid, decreased Aβ-stimulated TNF-α secretion by murine microglia (P < 0.05).
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