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Activation of PPG neurons following acute stressors differentially involves hindbrain serotonin in male rats
Activation of appetite-related neurons after stress involves hindbrain serotonin differently in male rats
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Abstract
Increased c-Fos expression in PPG neurons following lithium chloride and novel restraint stress is dependent on hindbrain 5-HT2C and 5-HT3 receptor signaling.
- Serotonin interacts with the central GLP-1 system through 5-HT2C and 5-HT3 receptors, influencing feeding behavior.
- The central GLP-1 system is activated by various stressors and is involved in stress-related behaviors.
- Increased c-Fos expression in PPG neurons indicates neuronal activation in response to specific stressors.
- Only lithium chloride and novel restraint stress, but not noncontingent cocaine, activate PPG neurons via 5-HT signaling.
- RMg neurons, which express serotonin, project to NTS PPG neurons, indicating a direct pathway for serotonin's modulatory effects.
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