Serotonergic modulation of the activity of GLP-1 producing neurons in the nucleus of the solitary tract in mouse

Jul 29, 2017Molecular metabolism

How serotonin affects the activity of appetite-regulating neurons in the brainstem of mice

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Abstract

Close appositions from 5-HT-immunoreactive axons occurred on many PPG neurons.

  • PPG neurons in the nucleus tractus solitarius may receive serotonergic input.
  • Application of 20 μM 5-HT induced significant increases in calcium responses in PPG dendrites.
  • Dendritic calcium spikes were concentration-dependent and not influenced by blocking glutamate signals.
  • Inhibition of 5-HT receptors reduced increases in intracellular calcium levels.
  • 44% of PPG neurons decreased their firing rate in response to 5-HT, an effect reversible by receptor antagonism.
  • These findings indicate that interactions between 5-HT and PPG neurons could be involved in regulating food intake.

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