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Pramlintide, an amylin analog, selectively delays gastric emptying: potential role of vagal inhibition
Pramlintide, a drug like amylin, slows stomach emptying by possibly affecting nerve signals
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Abstract
Pramlintide at doses of 30 and 60 micrograms delays gastric emptying by more than 60 minutes compared to placebo.
- Gastric emptying half-times were 112 minutes for placebo, 169 minutes for 30 micrograms, and 177 minutes for 60 micrograms of pramlintide.
- No significant effects on small bowel or colonic transit were observed with pramlintide treatment.
- Pancreatic polypeptide levels were lower in the first hour after a meal with pramlintide compared to placebo.
- A moderate inverse correlation was found between pancreatic polypeptide levels and gastric emptying rates.
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