Full text is available at the source.
Abstract
Prime editing represents a rapidly evolving family of genome editing technologies.
- The review highlights the technological evolution of prime editing from its initial 'search-and-replace' methodology.
- Key areas of focus include the architecture of editing tools and advancements in guide RNA design.
- Delivery methods for prime editing are examined, illustrating various strategies for effective application.
- Therapeutic applications of prime editing are explored, indicating potential uses in medicine.
- Computational approaches related to prime editing are discussed, showcasing emerging capabilities in the field.
Simplified