Prospective Cohort Study of the Risk of Prostate Cancer among Rotating-Shift Workers: Findings from the Japan Collaborative Cohort Study

Jul 11, 2006American journal of epidemiology

Risk of prostate cancer in rotating-shift workers: results from a long-term Japanese study

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Abstract

Among 14,052 working men in Japan, rotating-shift workers had a threefold increased risk of prostate cancer compared to day workers.

The study prospectively assessed the relationship between shift work and prostate cancer incidence.
A total of 31 cases of prostate cancer were identified during 111,974 person-years of follow-up.
Rotating-shift work was linked to a relative risk of 3.0 for developing prostate cancer.
Fixed-night work showed a small and nonsignificant increase in prostate cancer risk.
This is the first report to demonstrate a significant association between rotating-shift work and prostate cancer.

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Shift workers have been reported to have an increased risk of some cancers. However, the risk of prostate cancer in shift workers is not known to have been examined previously. This study prospectively examined the association between shift work and risk of prostate cancer incidence among 14,052 working men in Japan enrolled in a large-scale prospective cohort. A baseline survey was conducted between 1988 and 1990. Subjects were asked to indicate the most regular work schedule they had undertaken previously: day work, rotating-shift work, or fixed-night work. During 111,974 person-years, 31 cases of prostate cancer were recorded. The Cox proportional hazards model was used to estimate the risk, with adjustments for age, family history of prostate cancer, study area surveyed, body mass index, smoking, alcohol drinking, job type, physical activity at work, workplace, perceived stress, educational level, and marriage status. Compared with day workers, rotating-shift workers were significantly at risk for prostate cancer (relative risk = 3.0, 95% confidence interval: 1.2, 7.7), whereas fixed-night work was associated with a small and nonsignificant increase in risk. This report is the first known to reveal a significant relation between rotating-shift work and prostate cancer.

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Prospective Cohort Study of the Risk of Prostate Cancer among Rotating-Shift Workers: Findings from the Japan Collaborative Cohort Study

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