A Prospective Cohort Study of Shift Work and Risk of Ischemic Heart Disease in Japanese Male Workers

May 19, 2006American journal of epidemiology

Shift work and risk of heart disease in Japanese male workers

AI simplified

Circadian Biology on OpenScience ↗PubMed ↗DOI ↗

Abstract

Among 17,649 Japanese male workers, rotating-shift work is associated with a 2.32-fold increased risk of death from ischemic heart disease compared to day work.

A total of 1,363 deaths were recorded during 233,869 person-years of follow-up, with 86 attributed to ischemic heart disease.
Rotating-shift workers face a significantly higher risk of ischemic heart disease-related death compared to those who work day shifts.
Fixed-night work does not show a significant association with ischemic heart disease mortality.
Individuals with coronary risk factors may be more susceptible to the negative effects of rotating-shift work on heart disease risk.

AI simplified

This study prospectively examined the association between shift work and the risk of ischemic heart disease among Japanese male workers. A baseline survey, which involved 110,792 inhabitants (age range: 40-79 years) from 45 areas throughout Japan, was conducted between 1988 and 1990. The causes of death were identified from death certificates. The analysis was restricted to 17,649 men (age range: 40-59 years) who were employed at the time of the baseline survey. All subjects were asked to indicate the most regular shift work that they had undertaken previously: day work, rotating-shift work, or fixed-night work. The Cox proportional hazards model was used to estimate the risks of shift work for ischemic heart disease. During the 233,869 person-years of follow-up, a total of 1,363 deaths were recorded, 86 of which were due to ischemic heart disease. Compared with the day workers, the rotating-shift workers had a significantly higher risk of death due to ischemic heart disease (relative risk = 2.32, 95% confidence interval: 1.37, 3.95; p = 0.002), whereas fixed-night work was not associated with ischemic heart disease (relative risk = 1.23, 95% confidence interval: 0.49, 3.10; p = 0.658). In addition, subjects with coronary risk factors, such as hypertension, overweight, habitual alcohol consumption, and smoking, were highly susceptible to the effect of rotating-shift work on the risk of death due to ischemic heart disease.

Full Text

Full text is available at the source.

View full text ↗

A Prospective Cohort Study of Shift Work and Risk of Ischemic Heart Disease in Japanese Male Workers

Abstract

Full Text

You found one interesting study. We’ll send the next 7.

what lands in your inbox each week:

Recent issues from the circadian biology brief

Abstract

Full Text

Related papers

You found one interesting study. We’ll send the next 7.

what lands in your inbox each week:

Recent issues from the circadian biology brief