Scientific dataMay 21, 2026

Brain and behavior changes with psilocybin in different situations using multiple brain imaging methods

Psychedelic Science Weekly Brief ↗PubMed ↗DOI ↗OA ↗

Updated Jun 27, 2026

Abstract

Essence

PsiConnect is an open multimodal study resource for probing how context and meditation shape psilocybin-related brain and behavior dynamics.

Evidence

A neuroimaging resource and protocol describes 62 participants receiving 19 mg psilocybin with MRI, EEG, resting-state and naturalistic tasks, meditation training in half the cohort, and follow-ups to one year.

Caveat

The abstract presents design and data-resource scope rather than outcome results, and the sample is modest for testing subgroup interactions.

Simplified

PsiConnect is a large-scale neuroimaging study designed to investigate context-dependent neural and subjective effects of psilocybin using multimodal neuroimaging. It combines functional, structural, and diffusion-weighted MRI with EEG to examine brain activity in 62 participants before and after a 19 mg dose of psilocybin. The design includes resting-state scans and three naturalistic conditions: guided meditation, music listening, and movie watching. Half of the cohort underwent an 8-week meditation training program, enabling exploration of interactions among meditation, psilocybin, and brain function. fMRI data was obtained through multi-echo fMRI, enhancing signal-to-noise ratio and reducing susceptibility artifacts to improve reliability. A comprehensive battery of behavioural and self-report measures captured acute and longitudinal cognitive and subjective effects, with follow-ups to one year post-administration. The large sample, multimodal imaging, contextual diversity, and behavioural follow-ups enable study of psilocybin-induced brain and behaviour changes with unprecedented comprehensiveness and reliability. Data is curated according to open science principles to ensure accessibility and compatibility with established neuroimaging pipelines, making PsiConnect a valuable, reusable resource for cognitive and computational neuroscience.

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Brain and behavior changes with psilocybin in different situations using multiple brain imaging methods

Abstract

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