We can’t show the full text here under this license.
Single dose of psilocybin quickly and lasting reduces pain sensitivity and anxiety-depression behaviors in mice with chronic pain
Updated
Abstract
Essence
A single psilocybin dose rapidly and durably eased pain sensitivity and anxiodepressive-like behavior in mouse models of chronic pain.
Evidence
This preclinical mouse study used two chronic pain models, local psilocin injections, pharmacologic receptor manipulations, and two-photon calcium imaging to link the behavioral effects to prefrontal cortical circuits and normalization of anterior cingulate hyperactivity.
Caveat
The evidence is limited to animal models, and receptor agonists reproduced only some of psilocin's cellular and behavioral effects.
Simplified
Key numbers
12 days
Complete Reversal of Mechanical Hypersensitivity
Duration of effect post psilocybin injection in pain models.
0.00011
Improvement in Anxiety-like Behaviors
P-value indicating significant improvement in anxiety-like behaviors post-treatment.
Psychedelic Science