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Abstract
Essence
A single psilocybin dose rapidly and durably eased pain sensitivity and anxiodepressive-like behavior in mouse models of chronic pain.
Evidence
This preclinical mouse study used two chronic pain models, local psilocin injections, pharmacologic receptor manipulations, and two-photon calcium imaging to link the behavioral effects to prefrontal cortical circuits and normalization of anterior cingulate hyperactivity.
Caveat
The evidence is limited to animal models, and receptor agonists reproduced only some of psilocin's cellular and behavioral effects.
Simplified
Psychedelic Science