Psilocybin with early palliative care for feelings of hopelessness and long-term pain: a preliminary open study

Psilocybin-assisted therapy (PAT) may improve symptoms of demoralization and chronic pain in early palliative care.

• Demoralization is characterized by feelings of helplessness, hopelessness, and loss of meaning.
• Chronic pain is often a significant source of distress for patients in palliative care.
• Preliminary data indicate that PAT could lead to improvements in pain levels and feelings of demoralization.
• PAT has not been previously studied in patients experiencing both demoralization and chronic pain.
• This intervention has yet to be integrated into routine outpatient palliative care settings.

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