Psilocybin improves learning of place preference in planarians

Psilocybin-treated planarians showed a significantly greater shift in light preference compared to controls.

• A single exposure to 5 µM psilocybin was used to assess its effects on associative learning in planarians.
• Planarians underwent 5 days of conditioning where light was paired with sucrose.
• The significant interaction observed (F(2,38) = 3.3, P < 0.05) indicates enhanced appetitive learning in psilocybin-treated planarians.
• Effects of psilocybin on learning persisted for at least 6 days post-administration.
• These findings suggest that psilocybin may influence neuroplasticity via conserved serotonergic mechanisms.

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