Metabolism of psilocybin and psilocin: clinical and forensic toxicological relevance

Psilocybin is primarily converted to psilocin, an active metabolite involved in its psychoactive effects.

• Psilocybin and psilocin are hallucinogenic compounds found in magic mushrooms.
• Both compounds act as agonists or partial agonists at serotonin receptors.
• Considerable physiological variability among individuals may affect their dose-response and toxicity.
• Psilocin is the main psychoactive component resulting from the metabolism of psilocybin.
• The primary urinary metabolite of psilocin, psilocin-O-glucuronide, has clinical and forensic relevance.

AI simplified