Psychedelic therapy in depression and substance use disorders

Psychedelics may offer promising potential in treating neuropsychiatric diseases where conventional treatments are insufficient.

• Psychoactive substances from botanicals have been used in rituals for thousands of years.
• Classical psychedelics like psilocybin and LSD affect perception, emotion, and cognition by activating serotonin receptors.
• Research into psychedelics was largely halted after legislation in 1967 but has gained renewed interest since the 1990s.
• Recent studies indicate that psychedelics could be effective in treating conditions such as treatment-resistant depression and substance use disorders.
• The discussion includes the historical development of psychedelic therapy and its ethical implications.

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