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Abstract
Quercetin treatment significantly alleviated depressive-like behaviors and improved glucose metabolic dysregulation in rats subjected to chronic unpredictable mild stress.
- Quercetin modified bile acid composition in the colonic contents of the rats.
- Activation of the bile acid-farnesoid x receptor (FXR) and takeda g protein-coupled receptor 5 (TGR5) signaling pathway was observed following quercetin treatment.
- Secretion of glucagon-like peptide-1 (GLP-1) was enhanced with quercetin administration.
- These changes are associated with improved glycemic and lipid homeostasis.
- Quercetin may serve as a dual-target therapeutic agent for stress-related metabolic and neurobehavioral disorders.
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