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Remodeling gut microbiota and enhancing SCFA production in mice: mechanisms of RS2 and arabinoxylan in ameliorating PCOS phenotypes
How Resistant Starch and Arabinoxylan Change Gut Bacteria and Increase Short-Chain Fatty Acids to Improve PCOS Symptoms in Mice
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Abstract
RS2 and AX reduced body weight and improved insulin sensitivity in mice over 35 days.
- Insulin sensitivity improved as indicated by lower HOMA-IR levels (p < 0.05).
- Regular estrous cycles were restored in RS2 and AX treated PCOS mice.
- The treatment reduced the presence of ovarian cystic follicles in the PCOS model.
- Increased levels of Ligilactobacillus were observed in the gut microbiota of treated groups (p < 0.05).
- Higher serum levels of , specifically acetic acid and butyrate, were associated with the interventions.
- Increased expression of AMPK signaling proteins was noted in the liver of treated PCOS mice (p < 0.05).
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Key numbers
p < 0.05
Decrease in HOMA-IR
Significant reduction in insulin resistance markers in RS2 and AX groups.
36 mice
Weight Loss
Total number of healthy female C57BL/6 mice used in the interventions.