Renal inflammaging: Mechanisms, pathophysiology and therapeutic prospects

Chronic kidney disease (CKD) is linked to accelerated ageing driven by chronic low-grade inflammation.

• The kidney is an active participant in systemic inflammaging rather than a passive target.
• Renal cells can develop a secretory phenotype that contributes to ongoing inflammation and organ decline.
• Key mechanisms involved in CKD include immune system aging, changes in metabolism, and cellular aging.
• Specific renal conditions such as diabetic nephropathy and the transition from acute kidney injury to CKD are influenced by these processes.
• New diagnostic methods and potential therapies are being explored to manage renal inflammaging effectively.

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